I-SHOU University / Prof. Chang Shu-Chen

 Pain Points Solved 

Aphthous ulcers are a common ulcerative disease of the oral mucosa. The surface of an oral ulcer is typically covered by a layer of yellow-gray pseudomembrane, composed mainly of fibrin exudates and necrotic tissue, which may block drug permeation. Therefore, this technology utilizes catechol groups to modify hyaluronic acid, preparing a sticky dopamine-hyaluronic acid derivative as the patch substrate. Simultaneously, Vitamin B2 is added to the patch substrate to create a stomatitis microneedle patch. Through painless microneedle puncture, it breaks through the pseudomembrane barrier, thereby transporting the drug on the patch to the epithelial mucosal layer to promote the repair of oral ulcers.

 Technology Introduction 

This technology utilizes dopamine to modify hyaluronic acid to synthesize an adhesive derivative. Using microneedles as a transdermal drug delivery pathway, an adhesive and biodegradable microneedle patch was developed, incorporating licorice extract and Vitamin B2 into the microneedle patch.

Figure1. Breaking through the pseudomembrane barrier via painless microneedle puncture, thereby transporting the drug on the patch to the epithelial mucosal layer to promote oral ulcer repair.

 Application Examples 

Using catechol groups to modify hyaluronic acid to prepare a sticky dopamine-hyaluronic acid derivative as the patch substrate; simultaneously adding Vitamin B2 to the patch substrate to prepare a microneedle patch for stomatitis.

 Related Links 

None

 Patent Name and Number 

None

 Industry-Academia / Tech Transfer Partner 

Industry-Academia: YJ. Biotechnology Co.,Ltd.

 Honors and Awards  

None

 Technical Contact  

Yu-Hui Huang, Manager

I-SHOU University
Tel: +886 7-6577711 ext. 2194
Email: yuhuihuang@isu.edu.tw