National University of Kaohsiung /  Prof. WANG, RUEY CHI

 Pain Points Solved 

By combining Graphene Oxide (GO) with Zinc Oxide (ZnO) as an alternative to traditional noble metal materials, and coupling it with a portable Raman spectrometer, this system enables the rapid, cost-effective, and precise detection of toxic substances. The technology demonstrates high sensitivity even at trace levels, serving as a powerful new tool for safeguarding public food safety.

 Technology Introduction 

The system is applied in the detection of biochemical and toxic compounds. By integrating a sensing chip that generates the SERS (Surface-Enhanced Raman Scattering) effect, it captures the specific Raman spectral signals of target molecules. These signals act as unique fingerprints, enabling highly accurate identification and distinct characterization of substances.

Figure 1. This SERS sensing substrate utilizes the abundant dipoles on graphene oxide to enhance the Raman signals of target molecules.

Figure 2.Image of the finished sensing substrate

 Application Examples 

Zinc Oxide (ZnO) is cost-effective, non-toxic, and highly efficient, requiring a thin layer of only 10 nm. The fabrication process is streamlined, achieving optimal enhancement effects through controlled thermal treatment or UV irradiation parameters. 
The resulting system boasts an Enhancement Factor (EF) of up to 10 million of Detection (LOD) at the ppb level (parts per billion). Furthermore, it exhibits high uniformity and exceptional stability, allowing for long-term storage at room temperature under ambient conditions
Our team has developed a novel sensing chip designed to amplify signals from trace molecules with high sensitivity, molecular specificity, and a high enhancement factor. The Graphene Oxide (GO) within the GO/ZnO composite is prepared via a solution-based method, ensuring low production costs and scalability. This technology presents significant opportunities for technology transfer and commercialization.

 Related Links 

None

 Patent Name and Number 

WANG, RUEY CHI (TW);
CHEN, YU HSUAN (TW)

SURFACE-ENHANCED RAMAN SCATTERING SENSING SUBSTRATE HAVING GRAPHENE OXIDE COMPOSITE FILM AND MANUFACTURING METHOD THEREOF 

Taiwan patent I642620，2018/12/1 -2037/8/30

 Industry-Academia / Tech Transfer Partner 

None

 Honors and Awards  

None

 Technical Contact  

Vivian Lee, Administrative Assistant 

National University of Kaohsiung
Tel: +886 7-5916639
Email: vivianlee@nuk.edu.tw