National Pingtung University of Science and Technology /  Assistant Professor Rank Research Fellow, Wei-Wen Sung

 Pain Points Solved 

1. Animal Welfare & 3R Spirit: Addresses the global demand for Reduction, Replacement, and Refinement by creating platforms that can replace animal testing.
2. In Vivo Mimicry: Overcomes the limitations of 2D cultures by using organ-on-a-chip technology to simulate a growth environment closer to that in vivo.
3. R&D Efficiency: Provides a standardized procedure for screening anti-inflammatory effects of natural extracts and synthetic compounds.

 Technology Introduction 

This project utilizes organ-on-a-chip technology to establish a 3D immune cell culture model. By integrating syringe pumps to create dynamic flow conditions, the platform evaluates the anti-inflammatory or immune-modulating responses of candidate substances, such as carbon dot compounds. The research encompasses cross-disciplinary fields including microfluidics, bioinformatics, and medical device regulations.

Figure 1. 3D cell culture equipment for conditional testing, where the red and dark blue parts are the liquids used in the test

 Application Examples 

1. Carbon Dot Screening: Several candidate compounds have been identified for inhibiting inflammation in the THP-1 human lymphoma cell line.
2. Platform Services: Provision of pre-cultured organ-on-a-chip systems to industry-academia partners for substance efficacy testing.

 Related Links 

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 Patent Name and Number 

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 Industry-Academia / Tech Transfer Partner 

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 Honors and Awards  

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 Technical Contact  

Joan Li, Project Manager

National Pingtung University of Science and Technology
Tel: +886 8-7703202 ext. 6571
Email: joanli@mail.npust.edu.tw