Kaohsiung Medical University / Prof.  Chia-Hsien Feng

 Pain Points Solved 

• Conventional polyamine analysis is time-consuming, complex, and relies heavily on organic solvents, raising environmental concerns.
• Existing methods are unsuitable for rapid screening of blood and food samples, limiting clinical and food safety applications.
• This technology offers a fast, low-cost, and environmentally friendly detection method with a reaction time under seven minutes.

 Technology Introduction 

Polyamines are cancer biomarkers. If cancer patients consume foods containing high concentrations of polyamines for a long time, the proliferation and migration of cancer cells will increase. The present invention is to develop a rapid and environmentally friendly polyamine detection method to measure the content of polyamines in blood and food. In this reagent kit, polyamines react with derivatization reagents within seven minutes and are extracted using ice-bath-effervescence-assisted salting-out extraction. Finally, polyamine derivatives in blood and food samples are successfully detected using capillary liquid chromatography coupled with ultraviolet light detection.

 Application Examples 

• Applied to monitor polyamine levels in cancer patients’ blood for disease assessment and dietary management.
  
• Used to determine polyamine content in foods, reducing excessive intake risks for high-risk populations.
• Suitable for adoption by clinical laboratories and food safety inspection agencies.

 Related Links 

None

 Patent Name and Number 

TW I874225
US 18/735,231

 Industry-Academia / Tech Transfer Partner 

None

 Honors and Awards  

None

 Technical Contact  

Mr. Hung, Assistant Manager

Kaohsiung Medical University 
Tel: +886 7-3121101 ext. 2360
Email: R121084@kmu.edu.tw